Alcohol Hypersensitivity In CRSwNP And Polyphenols

Alcohol sensitivity is reported in up to 74-86.5% of patients with chronic rhinosinusitis nasal polyposis (CRSwNP) and especially those aspirin-exacerbated respiratory disease (AERD). These typically report beverages fermented wood casks, fruit skins, or hops, but not other alcohol-containing drinks. We speculated that alcohol AERD/CRSwNP could result from activation basophils by polyphenols derived the aging beverages. collected whole blood samples controls sensitive subjects AERD/CRSwNP. exposed these cells red wine extract, various bioactive known be present wine, ethanol, as well positive controls. evaluated basophil via flow cytometry using CD63. Basophils were defined within a side scatterlow CCR3high gate. demonstrated robust (increased CD63 expression 0.72%±0.21 25.97%±5.35;n=4; p<0.018) response components extract. No significant changes observed control subjects. was ethanol. However, we ascribe immune active including either (+)-catechin resveratrol. Up alcoholic beverages, primarily associated wooden casks. – itself can directly activate basophils. able define specific substance(s) aged produce hypersensitivity reactions.